Hirudin



Hirudin (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts fibrinogen to fibrin upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The images at the left and at the right correspond to one representative Hirudin, i.e. the NMR Structure of Hirudin (1hic).

Hirudin
1hic, 2hir, 4hir, 5hir, 6hir – Hir – NMR

2joo - Hir – NMR

Hirudin + Thrombin light and heavy chains
1hrt, 3htc, 4htc - Hir +hThr L&H chains

3da9 - Hir peptide+hThr L&H chains

Hirugen + Thrombin light and heavy chains
2zhe, 2zhf, 2zhw, 2zg0, 2zfq, 2zfr, 1c5l, 1hxf, 1hah, 1hai, 1abi, 1abj, 1hgt, 2uuf - Hirg+ hThr L&H chains

Hirugen + Prothrombin
2cn0, 3c1k – Hirg+ hProThr 1t4u, 1t4v, 1o5g, 1g30, 1g32 - Hirg+hProThr+inhibitor

Hirugen + Prethrombin
1hag – Hirg+hPreThr

Hirugen + Thrombin heavy chain
1nm6 – Hirg+ hThr H chain

1nt1 - Hirg+ hThr H chain+inhibitor

Hirugen + Thrombin light and heavy chains+inhibitor
1fph - Hirg +hThr L&H chains+polypeptide

1hxe - Hirg +hThr L&H chains+Rb

1ypk, 1riw, 1mu6, 1mu8, 1mue, 1no9, 1oyt, 1o2g, 1ny2, 1gj4, 1gj5, 1kts, 1ktt, 1ghv, 1ghw, 1ghx, 1ghy, 1h8i, 1h8d, 1c5n, 1c5o, 1c1u, 1c1v, 1c1w, 1qj1, 1qj6, 1qj7, 1qbv, 1bcu, 1a2c, 1a61, 1a46, 1a5g, 1b5g, 1ad8, 1ai8, 1tom, 1bmm, 1bmn, 1lhc, 1lhd, 1lhe, 1lhf, 1lhg, 1uma, 1aht, 1fpc, 3hat, 1tmu, 1dwb, 1dwc, 1dwd, 1dwe, 1tmb, 3f68, 3eq0, 3dt0, 3dux, 3dhk, 2znk, 2zo3, 3d49, 2zhq, 2zi2, 2ziq, 2zff, 2zfp, 2zgb, 2zgx, 2zf0, 2zc9, 2zda, 2zdv, 3egk, 2pw8, 3c27, 2r2m, 2cf8, 2cf9, 2bdy, 2v3h, 2v3o, 1w7g, 1ype, 1ypg, 1ypj, 3biu, 3biv, 1doj, 1ypl, 1ypm, 1vzq, 1way, 1wbg, 1k21, 1k22, 1afe, 1ae8 – Hirg+ hThr L&H chains+inhibitor

Hirugen+Thrombin light and heavy chains+epsilon-thrombin
1vit - Hirg+hThr L&H chains+epsilon-hThr

Hirugen+ α-Thrombin +inhibitor
1zrb, 1z71, 1sl3, 1ta2, 1ta6, 1zgi, 1zgv, 2uuk, 2uuj, 2jh0, 2jh5, 2jh6, 2c8w, 2c8x, 2c8y, 2c8z, 2c90, 2c93, 8kme  – Hirg+α-hThr+inhibitor